Currently Informatica 9.5.1 is running on AS400 V6R1 normally, and my client plans to upgrade OS from AS400 V6R1 to AS400 V7R3. So we have no idea if 9.5.1 can run on V7R3.
Informatica 9.5.1 is out of support. You should upgrade to Informatica latest version 10.5.
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